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Systemic administration of 1 R, 4 S ‐4‐amino‐cyclopent‐2‐ene‐carboxylic acid, a reversible inhibitor of GABA transaminase, blocks expression of conditioned place preference to cocaine and nicotine in rats
Author(s) -
Ashby Charles R.,
Paul Mousumi,
Gardner Eliot L.,
Gerasimov Madina R.,
Dewey Stephen L.,
Len Ian C.,
Taylor Stephen J.C.
Publication year - 2002
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.10052
Subject(s) - conditioned place preference , nicotine , transaminase , pharmacology , chemistry , aminobutyric acid , systemic administration , carboxylic acid , stereochemistry , biochemistry , medicine , enzyme , biology , receptor , microbiology and biotechnology , in vivo
We examined the effect of 1 R, 4 S ‐4‐amino‐cyclopent‐2‐ene‐carboxylic acid (ACC), a reversible inhibitor of GABA transaminase, on the expression of conditioned place preference response to cocaine and nicotine in rats. Cocaine (20 mg/kg i.p.) and nicotine (0.4 mg/kg s.c.), but not vehicle or 300 mg/kg i.p. of ACC, produced a significant conditioned place preference response. Pretreatment of animals with 300 and 75 mg/kg i.p. of ACC significantly attenuated the expression of the cocaine‐ and nicotine‐induced conditioned place preference responses, respectively. These results are the first to suggest that reversible inhibition of GABA transaminase may be useful in blocking cue‐induced relapse to nicotine and cocaine. Synapse 44:61–63, 2002. © 2002 Wiley‐Liss, Inc.