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Repeated cocaine administration increases GABA B(1) subunit mRNA in rat brain
Author(s) -
Yamaguchi Mika,
Suzuki Toshihito,
Abe Shuzo,
Baba Atsuomi,
Hori Takafumi,
Okado Nobuo
Publication year - 2001
Publication title -
synapse
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.809
H-Index - 106
eISSN - 1098-2396
pISSN - 0887-4476
DOI - 10.1002/syn.10037
Subject(s) - nucleus accumbens , sensitization , gabab receptor , hippocampus , pharmacology , messenger rna , behavioral sensitization , in situ hybridization , thalamus , baclofen , protein subunit , medicine , endocrinology , chemistry , neuroscience , receptor , psychology , gabaa receptor , agonist , biochemistry , gene
The effects of a single and repeated administration of cocaine on GABA B receptor subunit mRNA was investigated in rat brain by in situ hybridization. Following a single administration of cocaine, no significant change was observed in any brain regions examined, neither 1 h nor 24 h after administration. During repeated administration of cocaine, behavioral sensitization with increased stereotyped behavior was observed. A significant increase in the level of GABA B(1) mRNA was observed in the nucleus accumbens (11.4%), CA1 field of the hippocampus (16.8%), and thalamus (16.5%) 1 day after repeated administrations of cocaine for 14 consecutive days. The level of mRNA returned to the basal level 1 week after the final injection of repeated cocaine treatment. The observed changes in the mRNA level after the repeated cocaine may imply changes of GABA B(1) subunit in molecular mechanisms which underlie development of behavioral sensitization. Synapse 43:175–180, 2002. © 2002 Wiley‐Liss, Inc.