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Premium In vivo microdialysis and conditioned place preference studies in rats are consistent with abuse potential of tramadol
Author(s)
Sprague Jon E.,
Leifheit Michael,
Selken Jennifer,
Milks Michael M.,
Kinder David H.,
Nichols David E.
Publication year2002
Publication title
synapse
Resource typeJournals
PublisherJohn Wiley & Sons
Abstract The abuse potential of tramadol was investigated using both in vivo microdialysis measures of dopamine (DA) release within the nucleus accumbens (NAc) shell and the conditioned place preference (CPP) paradigm in rats. Tramadol (75 mg/kg, i.p.) induced a statistically significant increase (starting 80 min posttreatment) in DA release within the NAc shell, which was maintained for at least 120 min posttreatment. Tramadol (18.75, 37.5, and 75 mg/kg i.p.) produced a statistically significant CPP, with the effects of the two highest doses comparable to those induced by morphine (5 mg/kg, s.c.). The release of DA within the NAc shell may be responsible for the rewarding properties of tramadol and, together with the CPP results, provide evidence that tramadol may possess greater abuse potential than originally believed. Synapse 43:118–121, 2002. © 2001 Wiley‐Liss, Inc.
Subject(s)analgesic , anesthesia , biology , chemistry , conditioned place preference , dopamine , in vivo , medicine , microbiology and biotechnology , microdialysis , morphine , nucleus accumbens , pharmacology , tramadol
Language(s)English
SCImago Journal Rank0.809
H-Index106
eISSN1098-2396
pISSN0887-4476
DOI10.1002/syn.10025

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