Open AccessConcise Review: Expanding Roles for Hematopoietic Cellular Therapy and the Blood Transfusion Services
Author(s) -
Hodby Katharine,
Pamphilon Derwood
Publication year - 2011
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.689
Subject(s) - stem cell , biology , haematopoiesis , progenitor cell , bone marrow , hematopoietic stem cell transplantation , hematopoietic stem cell , regenerative medicine , immunology , microbiology and biotechnology
Abstract Hematopoietic stem cells (HSCs) have remained at the forefront of stem cell research for the past 50 years, since the therapeutic potential of bone marrow transplantation was realized. Uniquely, among stem and progenitor cells, research progress has been made in parallel between the laboratory benchtop and hospital bedside during this period. Integral to this work has been the role of the transfusion medicine services in the collection, storage, and processing of HSCs. The next decade promises to bring further developments: with new fields of cellular therapies, stem cell vaccination, and stem cell drug testing opening up. This article summarizes exciting areas of research concerning the behavior and potential clinical applications of HSCs. For the purposes of clarity, we describe in turn the trafficking and transfer of HSCs; ex vivo expansion of HSC units from different sources; and finally, applications of specifically selected subsets of hematopoietic cells and their progeny. S TEM C ELLS 2011;29:1322–1326