Open AccessHuman Gastrointestinal Neoplasia‐Associated Myofibroblasts Can Develop from Bone Marrow‐Derived Cells Following Allogeneic Stem Cell Transplantation
Author(s) -
Worthley Daniel L.,
Ruszkiewicz Andrew,
Davies Ruth,
Moore Sarah,
NivisonSmith Ian,
Bik To L.,
Browett Peter,
Western Robyn,
Durrant Simon,
So Jason,
Young Graeme P.,
Mullighan Charles G.,
Bardy Peter G.,
Michael Michael Z.
Publication year - 2009
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.63
Subject(s) - biology , stromal cell , pathology , bone marrow , stroma , stem cell , transplantation , fluorescence in situ hybridization , immunohistochemistry , cancer , cancer research , immunology , medicine , biochemistry , genetics , gene , chromosome
This study characterized the contribution of bone marrow‐derived cells to human neoplasia and the perineoplastic stroma. The Australasian Bone Marrow Transplant Recipient Registry was used to identify solid organ neoplasia that developed in female recipients of male allogeneic stem cell transplants. Eighteen suitable cases were identified including several skin cancers, two gastric cancers, and one rectal adenoma. Light microscopy, fluorescence and chromogenic in situ hybridization, and immunohistochemistry were performed to determine the nature and origin of the neoplastic and stromal cells. In contrast to recent reports, donor‐derived neoplastic cells were not detected. Bone marrow‐derived neoplasia‐associated myofibroblasts, however, were identified in the rectal adenoma and in a gastric cancer. Bone marrow‐derived cells can generate myofibroblasts in the setting of human gastrointestinal neoplasia. S TEM C ELLS 2009;27: 1463–1468