Open AccessInvestigation of the impact of radiation dose on hormones, biologically active metabolites and immunoglobulins in chernobyl accident recovery workers
Author(s) -
Souchkevitch Guennadi,
Lyasko Ludmila
Publication year - 1997
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.5530150722
Subject(s) - metabolite , hormone , biology , biological activity , medicine , endocrinology , prostaglandin , antibody , physiology , toxicology , immunology , biochemistry , in vitro
One hundred twenty‐five Chernobyl accident recovery workers (liquidators) who were exposed to low‐dose radiation were studied over a period of 4‐6 years for changes in levels of hormones, arachidonic acid metabolites and cyclic nucleotides. Some significant changes were observed, especially in the levels of metabolites that are regulators of cell functions. In comparison to controls, there were increased levels of thyroxin, cortisol, thromboxane B 2 , and immunoglobulins G, A and M, and reduced levels of growth hormone, cyclic nucleotides and 6‐keto‐prostaglandin F 1. The degree or presence of these metabolite imbalances did not correlate with the level of the radiation dose received. The only change found that did relate to the radiation dose received was a statistically significant increase in levels of biomarkers for oxidative stress, seen in workers who received higher doses. Stem Cells 1997; 15(suppl 2): 151‐154