Open AccessEngineered stem cells targeting multiple cell surface receptors in tumors
Author(s) -
Kavari Sanam L.,
Shah Khalid
Publication year - 2020
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.3069
Subject(s) - biology , cancer stem cell , stem cell , cancer research , cancer cell , receptor , microbiology and biotechnology , tumor microenvironment , endothelial stem cell , tropism , cancer , immunology , tumor cells , in vitro , genetics , virus
Multiple stem cell types exhibit inherent tropism for cancer, and engineered stem cells have been used as therapeutic agents to specifically target cancer cells. Recently, stem cells have been engineered to target multiple surface receptors on tumor cells, as well as endothelial and immune cells in the tumor microenvironment. In this review, we discuss the rationales and strategies for developing multiple receptor‐targeted stem cells, their mechanisms of action, and the promises and challenges they hold as cancer therapeutics.