Open AccessConcise Review: TLR Pathway‐miRNA Interplay in Mesenchymal Stromal Cells: Regulatory Roles and Therapeutic Directions
Author(s) -
Abdi Jahangir,
Rashedi Iran,
Keating Armand
Publication year - 2018
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.2902
Subject(s) - biology , mesenchymal stem cell , microrna , microbiology and biotechnology , innate immune system , stromal cell , microvesicles , immune system , signal transduction , inflammation , toll like receptor , immunology , cancer research , gene , genetics
Abstract Mesenchymal stromal cells (MSCs) deploy Toll‐like receptors (TLRs) to respond to exogenous and endogenous signals. Activation of TLR pathways in MSCs alters their inflammatory profile and immunomodulatory effects on cells from both the innate and adaptive immune systems. Micro‐RNAs (miRNAs), whose expression is modulated by TLR activation, can regulate inflammatory responses by targeting components of the TLR signaling pathways either in MSCs or in the cells with which they interact. Here, we review how the miRNA‐TLR pathway axis can regulate the immunomodulatory functions of MSCs, including their interactions with monocytes/macrophages and natural killer cells, and discuss the therapeutic implications for MSC‐based therapies. Stem Cells 2018;36:1655–1662