Open AccessChallenges of Stem Cell Therapy for Spinal Cord Injury: Human Embryonic Stem Cells, Endogenous Neural Stem Cells, or Induced Pluripotent Stem Cells?
Author(s) -
Ronaghi Mohammad,
Erceg Slaven,
MorenoManzano Victoria,
Stojkovic Miodrag
Publication year - 2010
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.253
Subject(s) - biology , embryonic stem cell , induced pluripotent stem cell , spinal cord injury , neuroscience , neural stem cell , stem cell , spinal cord , neuroprotection , microbiology and biotechnology , biochemistry , gene
Spinal cord injury (SCI) causes myelopathy, damage to white matter, and myelinated fiber tracts that carry sensation and motor signals to and from the brain. The gray matter damage causes segmental losses of interneurons and motoneurons and restricts therapeutic options. Recent advances in stem cell biology, neural injury, and repair, and the progress toward development of neuroprotective and regenerative interventions are the basis for increased optimism. This review summarizes the pathophysiological mechanisms following SCI and compares human embryonic, adult neural, and the induced pluripotent stem cell‐based therapeutic strategies for SCI. S TEM C ELLS 2010;28:93–99