English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Receptor‐interacting protein 140 (RIP140) is a wide‐spectrum coregulator for hormonal regulation of gene expression, but its activity in development/stem cell differentiation is unknown. Here, we identify RIP140 as an immediate retinoic acid (RA)‐induced dual‐function chaperone for LSD1 (lysine‐specific demethylase 1). RIP140 protects LSD1's catalytic domain and antagonizes its Jade‐2‐mediated ubiquitination and degradation. In RA‐induced neuronal differentiation, the increased RIP140/LSD1 complex is recruited by RA‐elevated Pit‐1 to specifically reduce H3K4me2 modification on the  Pax6  promoter, thereby repressing RA‐induction of  Pax6 . This study reveals a new RA‐induced gene repressive mechanism that modulates the abundance, enzyme quality, and recruitment of histone modifier LSD1 to neuronal regulator  Pax6 , which provides a homeostatic control for RA induction of neuronal differentiation. S tem  C ells   2016;34:114–123

Retinoic Acid Induces Ubiquitination‐Resistant RIP140/LSD1 Complex to Fine‐Tune P ax6 Gene in Neuronal Differentiation