Open AccessConcise Reviews: Characteristics and Potential Applications of Human Dental Tissue‐Derived Mesenchymal Stem Cells
Author(s) -
Liu Junjun,
Yu Fang,
Sun Yao,
Jiang Beizhan,
Zhang Wenjun,
Yang Jianhua,
Xu GuoTong,
Liang Aibin,
Liu Shangfeng
Publication year - 2015
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.1909
Subject(s) - stem cell , mesenchymal stem cell , periodontal ligament stem cells , dental follicle , biology , dental pulp stem cells , stem cell transplantation for articular cartilage repair , progenitor cell , clinical uses of mesenchymal stem cells , dental papilla , microbiology and biotechnology , regenerative medicine , adult stem cell , endothelial stem cell , immunology , pathology , alkaline phosphatase , pulp (tooth) , medicine , in vitro , odontoblast , biochemistry , enzyme
Recently, numerous types of human dental tissue‐derived mesenchymal stem cells (MSCs) have been isolated and characterized, including dental pulp stem cells, stem cells from exfoliated deciduous teeth, periodontal ligament stem cells, dental follicle progenitor cells, alveolar bone‐derived MSCs, stem cells from apical papilla, tooth germ progenitor cells, and gingival MSCs. All these MSC‐like cells exhibit self‐renewal, multilineage differentiation potential, and immunomodulatory properties. Several studies have demonstrated the potential advantages of dental stem cell‐based approaches for regenerative treatments and immunotherapies. This review outlines the properties of various dental MSC‐like populations and the progress toward their use in regenerative therapy. Several dental stem cell banks worldwide are also introduced, with a view toward future clinical application. S tem C ells 2015;33:627–638