Open AccessConcise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
Author(s) -
Lv Feng-Juan,
Tuan Rocky S.,
Cheung Kenneth M.C.,
Leung Victor Y.L.
Publication year - 2014
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.1681
Subject(s) - mesenchymal stem cell , biology , cd146 , stem cell , microbiology and biotechnology , stem cell transplantation for articular cartilage repair , clinical uses of mesenchymal stem cells , cancer research , immunology , adult stem cell , in vitro , genetics , endothelial stem cell , cd34
The concept of mesenchymal stem cells (MSCs) is becoming increasingly obscure due to the recent findings of heterogeneous populations with different levels of stemness within MSCs isolated by traditional plastic adherence. MSCs were originally identified in bone marrow and later detected in many other tissues. Currently, no cloning based on single surface marker is capable of isolating cells that satisfy the minimal criteria of MSCs from various tissue environments. Markers that associate with the stemness of MSCs await to be elucidated. A number of candidate MSC surface markers or markers possibly related to their stemness have been brought forward so far, including Stro‐1, SSEA‐4, CD271, and CD146, yet there is a large difference in their expression in various sources of MSCs. The exact identity of MSCs in vivo is not yet clear, although reports have suggested they may have a fibroblastic or pericytic origin. In this review, we revisit the reported expression of surface molecules in MSCs from various sources, aiming to assess their potential as MSC markers and define the critical panel for future investigation. We also discuss the relationship of MSCs to fibroblasts and pericytes in an attempt to shed light on their identity in vivo. S tem C ells 2014;32:1408–1419