Open AccessParvoviruses and Bone Marrow Failure
Author(s) -
Brown Kevin E.,
Young Neal S.
Publication year - 1996
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1002/stem.140151
Subject(s) - parvovirus , biology , bone marrow , hydrops fetalis , immunology , bone marrow aplasia , aplastic anemia , bone marrow failure , erythropoiesis , tropism , anemia , pure red cell aplasia , parvoviridae , aplasia , virology , fetus , stem cell , medicine , virus , haematopoiesis , pregnancy , genetics , anatomy
Parvovirus B19, the only known human pathogenic parvovirus, is highly tropic to human bone marrow and replicates only in erythroid progenitor cells. The basis of this erythroid tropism is the tissue distribution of the B19 cellular receptor, globoside (blood group P antigen). In individuals with underlying hemolytic disorders, infection with parvovirus B19 is the primary cause of transient aplastic crisis. In immunocompromised patients, persistent B19 infection may develop that manifests as pure red cell aplasia and chronic anemia. B19 infection in utero can result in fetal death, hydrops fetalis or congenital anemia. Diagnosis is based on examination of the bone marrow and B19 virological studies. Treatment of persistent infection with immunoglobulin leads to a rapid, marked resolution of the anemia.