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Synthesis, Characterization, and Antifungal Activity of N‐Quaternized and N‐Diquaternized Chitin Derivatives
Author(s) -
Luan Fang,
Wei Lijie,
Zhang Jingjing,
Tan Wenqiang,
Chen Yuan,
Wang Ping,
Dong Fang,
Li Qing,
Guo Zhanyong
Publication year - 2018
Publication title -
starch ‐ stärke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 82
eISSN - 1521-379X
pISSN - 0038-9056
DOI - 10.1002/star.201800026
Subject(s) - chitin , antifungal , chemistry , minimum inhibitory concentration , fourier transform infrared spectroscopy , proton nmr , nuclear chemistry , organic chemistry , antimicrobial , microbiology and biotechnology , chitosan , biology , physics , quantum mechanics
To improve the bioactivity of chitin (CT), novel N‐quaternized (QCT), and N‐diquaternized (DQCT) CT derivatives are synthesized through a series of reactions from CT. The derivatives are characterized using elemental analysis, FTIR, and 13 C NMR. In addition, the inhibitory effects of the compounds against three fungi ( B. cinerea , F. oxysporum , and P. asparagi ) are tested. The inhibitory indices of CT, QCT, and DQCT are 12–15%, 63–73%, and 74–89%, respectively, at 1.0 mg mL −1 . The antifungal activities are in the order of DQCT > QCT > CT, which correlated with the number of quaternized groups. Based on these results, it is concluded that the antifungal activity of CT is improved by the introduction of quaternized groups on CT backbone.

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