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Synthesis of Novel Amino Lactose and Evaluation of Its Antioxidant Property
Author(s) -
Li Qing,
Feng Yan,
Gu Guodong,
Guo Zhanyong
Publication year - 2018
Publication title -
starch ‐ stärke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 82
eISSN - 1521-379X
pISSN - 0038-9056
DOI - 10.1002/star.201700293
Subject(s) - lactose , antioxidant , chemistry , hydrogen peroxide , derivatization , radical , dpph , combinatorial chemistry , biochemistry , organic chemistry , high performance liquid chromatography
In order to improve the bioactivity of lactose, a novel lactose derivative is designed and synthesized by introducing an amino group to the C‐6 of lactose. The in vitro antioxidant activities of synthesized lactose derivatives are assessed. It shows better scavenging activity against hydrogen peroxide (IC 50 < 0.1 mg mL −1 ), hydroxyl radicals (IC 50 0.55 mg mL −1 ), and DPPH radicals (IC 50 0.37 mg mL −1 ) than lactose. Based on this data, it is reasonable to propose that the introduction of amino group through chemical modification is significant to enhance the free antioxidant activity of lactose. This derivatization strategy might provide an effective tool to broaden utilization of lactose.