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Spectroscopic study of natural and synthetic polysaccharide sulfate structures
Author(s) -
Korva Hanne,
Kärkkäinen Johanna,
Lappalainen Katja,
Lajunen Marja
Publication year - 2016
Publication title -
starch ‐ stärke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 82
eISSN - 1521-379X
pISSN - 0038-9056
DOI - 10.1002/star.201600155
Subject(s) - polysaccharide , sulfate , chemistry , sulfation , nuclear magnetic resonance spectroscopy , chemical structure , carbon 13 nmr , organic chemistry , combinatorial chemistry , biochemistry
Sulfate‐containing polysaccharides are a diverse group of natural products and many of them have shown biological activity. Therefore, a growing interest has focused on the chemical preparation of sulfated derivatives from common polysaccharides. The analysis of these complicated, synthetically prepared polysaccharide sulfates typically requires the utilization of several methods. NMR and IR spectroscopy are routinely used to follow the progress of the sulfation reactions and to confirm the presence of covalently bonded sulfate groups in the products. Hence, they are important methods in the structural characterization of the compounds. In this review, the application of 1 H NMR, 13 C NMR, and IR spectroscopy to the analysis of synthetic polysaccharide sulfates is discussed with reference to carrageenans, which is a commercially significant group of natural polysaccharide sulfates whose structures have been extensively studied. As the spectra of carrageenans are well‐known, they can be utilized in the structure elucidation of related synthetic compounds.