Premium
6‐Gingerol inhibits fungal alpha amylase: Enzyme kinetic and molecular modeling studies
Author(s) -
Tintu Ignatius,
Dileep Kalarickal Vijayan,
Remya Chandran,
Augustine Anu,
Sadasivan Chittalakkottu
Publication year - 2012
Publication title -
starch ‐ stärke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 82
eISSN - 1521-379X
pISSN - 0038-9056
DOI - 10.1002/star.201200004
Subject(s) - enzyme , biochemistry , alpha amylase , chemistry , hydrolysis , amylase , docking (animal) , molecular model , starch , medicine , nursing
Alpha amylases are hydrolytic enzymes that are widespread in nature, being found in animals, microorganisms, and plants. These enzymes hydrolyze starch molecules into reducing sugars. Alpha amylases from microbial sources have several applications in industrial sectors. This enzyme is an effective target for the development of anti‐fungal agents. The binding affinity and enzyme inhibitory properties of 6‐gingerol toward alpha amylase have been determined. Molecular modeling and docking has been carried out, in order to get the molecular level interactions. Enzyme inhibition studies proved that 6‐gingerol is a competitive inhibitor of fungal alpha amylase. It was inferred that 6‐gingerol is a potent natural inhibitor of alpha amylase.