Premium
Synthesis and Evaluation of pH and Thermosensitive Pectin‐Based Superabsorbent Hydrogel for Oral Drug Delivery Systems
Author(s) -
Pourjavadi Ali,
Barzegar Shahram
Publication year - 2009
Publication title -
starch ‐ stärke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 82
eISSN - 1521-379X
pISSN - 0038-9056
DOI - 10.1002/star.200800063
Subject(s) - superabsorbent polymer , swelling , drug delivery , polymer , pectin , chemistry , scanning electron microscope , solvent , fourier transform infrared spectroscopy , self healing hydrogels , nuclear chemistry , chemical engineering , materials science , polymer chemistry , organic chemistry , composite material , biochemistry , engineering
The purpose of this study was to produce intelligent pectin‐based superabsorbent polymers (SAP) to be used as pH‐ and thermosensitive carriers for the controlled delivery of non‐steroidal anti‐inflammatory drugs (NSAIDs). The superabsorbent formation was confirmed by Fourier transform infrared spectroscopic (FT‐IR) and scanning electron microscopy (SEM). The effects of pH, ionic strength, temperature, porosity, particle size and levels of loaded drug on drug release profile in various surrounding media were investigated. Each sample was well characterized through swelling studies. The molecular weight between crosslinks $\displaystyle (\overline {{\tf="PS_HENI"M}}_C) $ , crosslinking density ( v e ) polymer–solvent interaction parameter (χ), and the shear modulus of the superabsorbents ( G ) were calculated. The results revealed that the release profiles of IBU from the superabsorbent polymer were low (lower than 14%) in simulated gastric fluid (SGF, pH 1.2) over 3 h, but nearly all of the initial drug content (more than 79%) was released in simulated intestinal fluid (SIF, pH 7.4) within 6 h after changing media. Overall the results demonstrated that biodegradable superabsorbents could successfully deliver a drug to the intestine without losing the drug in the stomach, and could be potential candidates for an orally administrated drug delivery system.