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Latentiation of Chemotherapeutics Agents Part 2: Synthesis of Oxidized Cellulose Imine Derivatives With Antimalarials
Author(s) -
Cruz Maria Luiza,
Ferreira Elizabeth Igne,
Korolkovas Andrejus
Publication year - 1997
Publication title -
starch ‐ stärke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 82
eISSN - 1521-379X
pISSN - 0038-9056
DOI - 10.1002/star.19970490206
Subject(s) - sulfadiazine , sulfone , chemistry , sulfisoxazole , plasmodium berghei , dapsone , parasitemia , sulfonamide , derivative (finance) , cellulose , organic chemistry , combinatorial chemistry , plasmodium falciparum , antibiotics , medicine , malaria , biochemistry , dermatology , economics , financial economics , immunology , tetracycline
Oxidized cellulose derivatives with sulfonamides and sulfone were synthesized in order to obtain antimalarials better than the now available. Derivatives of dapsone (ML14), sulfadiazine (ML17), sulfamethoxazole (ML18), sulfisoxazole (ML19), sulfamethoxypiridazine (ML20), sulfameter (ML22) were identified by usual spectrometric analysis (IR, UV, 1 H‐NMR). Submitted to preliminar biological assay, only three compounds avoided the parasitemia on the 5th day after treatment and of these, sulfadiazine derivative showed activity on the 30th day after treatment of mice infected with Plasmodium berghei .