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Synthesis of O‐Glycopeptiden
Author(s) -
Paulsen H.,
Adermann K.,
Merz G.,
Schultz M.,
Weichert U.
Publication year - 1988
Publication title -
starch ‐ stärke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 82
eISSN - 1521-379X
pISSN - 0038-9056
DOI - 10.1002/star.19880401204
Subject(s) - glycopeptide , glycosyl , threonine , serine , chemistry , amino acid , protecting group , galactose , stereochemistry , carbohydrate , glycoside , glycosyl donor , combinatorial chemistry , biochemistry , organic chemistry , phosphorylation , alkyl , antibiotics
Glycosyl halides of 2‐azido‐2‐deoxy‐D‐galactose derivatives can be selectively coupled to α‐glycosides with the hydroxyl groups of L‐serine and L‐threonine derivatives. Using adequate protecting groups further reactions with any amino acid are possible with the obtained carbohydrate amino acid compounds after the deprotection of the N‐ or C‐terminus. Among others examples from the field of glycophorines and interleukine‐2 are described. This method is also suitable for the synthesis of glycopeptides on solid support.