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Cyclodextrins in Biotechnology
Author(s) -
Szejtli J.
Publication year - 1986
Publication title -
starch ‐ stärke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 82
eISSN - 1521-379X
pISSN - 0038-9056
DOI - 10.1002/star.19860381107
Subject(s) - detoxication , chemistry , substrate (aquarium) , hydrolysis , enzyme , cyclodextrin , solubility , aqueous solution , biochemistry , organic chemistry , biology , ecology
Cyclodextrins and their derivatives enhance the solubility of complexed substrates in aqueous media, but do not damage the microbial cells or the enzymes. Therefore the enzymatic conversion of lipophylic substrates can be intensified (accelerated, or performed at higher substrate concentration). Examples are the hydrolysis of triglycerides or conversion of hydrocortisone to prednisolon. In presence of an appropriate CD‐derivative (e. g. 2,6‐dimethyl‐β CD) the lipidlike inhibitor substances are complexed, therefore the propagation of Bordatella pertussis and the production of pertussis toxin increases up to 100‐fold. The tolerable level of toxic compounds at biological detoxication of sewage of organic chemical industry can be elevated by admixing small amount of β‐cyclodextrin to the system, because the complexed toxic substances do not kill the detoxicating microbes.