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A Study of Hydroxyethyl Starch. Part III. Comparison of Metabolic Fates between 2‐0‐Hydroxyethyl Starch and 6‐0‐Hydroxyethyl Starch in Rabbits
Author(s) -
Yoshida M.,
Minami Y.,
Kishikawa T.
Publication year - 1984
Publication title -
starch ‐ stärke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 82
eISSN - 1521-379X
pISSN - 0038-9056
DOI - 10.1002/star.19840360606
Subject(s) - hydroxyethyl starch , starch , chemistry , amylase , biochemistry , enzyme
The blood concentration, renal excretion, and molecular‐size distribution of 6‐O‐hydroxyethyl starch (6‐O‐HES) and 2‐O‐hydroxyethyl starch (2‐O‐HES), which were infused into rabbits, were compared. As a result, 6‐O‐HES showed a more rapid elimination from the body than 2‐O‐HES did, thus indicating that 6‐O‐HES was subjected to the same metabolic changes as 2‐O‐HES was, which had a lower molar substitution of hydroxyethyl groups by 0.2 to 0.3. This result might be attributed to the substitution‐site effect of hydroxyethyl groups on the enzymic degradation of hydroxyethyl starch by α‐amylase.