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Synthesis of Heptakis (2‐O‐methyl)‐β‐cyclodextrin
Author(s) -
Takeo K.,
Kuge T.
Publication year - 1976
Publication title -
starch ‐ stärke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 82
eISSN - 1521-379X
pISSN - 0038-9056
DOI - 10.1002/star.19760280704
Subject(s) - dextrin , chemistry , cyclodextrin , methylation , methyl benzoate , ether , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , starch , gene
The title compound was prepared by a reaction sequence comprising methylation of heptakis (6‐bromo‐6‐deoxy)‐β‐cyclodextrin by the Kuhn procedure, regeneration of the primary hydroxyl groups from the resulting heptakis(2‐O‐methyl‐6‐bromo‐6‐deoxy)‐β‐dextrin via the 6‐O‐benzoate ester by benzoate exchange and subsequent deesterification. It was proved that the methyl groups in the tetradeca‐O‐methyl ether of β‐dextrin are located 0–2 and 0–6 of the D‐glucose residues.