Sulfinylation on Superoxide Dismutase 1 Cys111: Novel Mechanism for 1‐Nitropyrene to Promote Acute Reactive Oxygen Species Generation | Zendy

Xie Guangshan | Zendy; Zhu Lin | Zendy; Zhang Yanhao | Zendy; Song Yuanyuan | Zendy; Zhang Hongna | Zendy; Yang Zhu | Zendy; Cai Zongwei | Zendy

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Sulfinylation on Superoxide Dismutase 1 Cys111: Novel Mechanism for 1‐Nitropyrene to Promote Acute Reactive Oxygen Species Generation

Author(s) -

Xie Guangshan,

Zhu Lin,

Zhang Yanhao,

Song Yuanyuan,

Zhang Hongna,

Yang Zhu,

Cai Zongwei

Publication year - 2021

Publication title -

small structures

Language(s) - English

Resource type - Journals

ISSN - 2688-4062

DOI - 10.1002/sstr.202170007

Subject(s) - reactive oxygen species , superoxide dismutase , sod1 , chemistry , superoxide , intracellular , oxygen , cytotoxicity , dismutase , radical , biochemistry , antioxidant , enzyme , in vitro , organic chemistry

1‐Nitropyrene In article number 2000123 , Zongwei Cai and co‐workers show that 1‐nitropyrene inhibits superoxide dismutase 1 (SOD1) activity to increase intracellular reactive oxygen species (ROS) by forming cysteine sulfinylation on Cys111 of SOD1. Therefore, a novel mechanism of 1‐nitropyrene‐induced acute cytotoxicity and ROS production is proposed.

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