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Sulfinylation on Superoxide Dismutase 1 Cys111: Novel Mechanism for 1‐Nitropyrene to Promote Acute Reactive Oxygen Species Generation
Author(s) -
Xie Guangshan,
Zhu Lin,
Zhang Yanhao,
Song Yuanyuan,
Zhang Hongna,
Yang Zhu,
Cai Zongwei
Publication year - 2021
Publication title -
small structures
Language(s) - English
Resource type - Journals
ISSN - 2688-4062
DOI - 10.1002/sstr.202170007
Subject(s) - reactive oxygen species , superoxide dismutase , sod1 , chemistry , superoxide , intracellular , oxygen , cytotoxicity , dismutase , radical , biochemistry , antioxidant , enzyme , in vitro , organic chemistry
1‐Nitropyrene In article number 2000123 , Zongwei Cai and co‐workers show that 1‐nitropyrene inhibits superoxide dismutase 1 (SOD1) activity to increase intracellular reactive oxygen species (ROS) by forming cysteine sulfinylation on Cys111 of SOD1. Therefore, a novel mechanism of 1‐nitropyrene‐induced acute cytotoxicity and ROS production is proposed.