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Microneedle Array Patches Integrated with Nanoparticles for Therapy and Diagnosis
Author(s) -
Hu Xiuli,
Zhang Huijuan,
Wang Zejun,
Shiu Chin Ying Angela,
Gu Zhen
Publication year - 2021
Publication title -
small structures
Language(s) - English
Resource type - Journals
ISSN - 2688-4062
DOI - 10.1002/sstr.202000097
Subject(s) - transdermal , nanotechnology , medicine , cancer therapy , materials science , cancer , pharmacology
Microneedle (MN)‐based techniques are widely explored these years for biomedical applications due to their convenience, high efficiency, and excellent patient compliance. The combination of MN array patches with nanoparticles (NPs) expands the applications of MNs with dynamic characteristics and facilitates on‐demand drug release while reducing systemic toxicity and enhancing therapeutic efficacy. This review summarizes the recent advances of MNs integrated with NPs as a transdermal approach for various applications. Representative therapeutic or diagnostic studies associated with diabetes, cancer, vaccine, obesity, hair growth, and acne vulgaris are highlighted in detail. Future perspectives for such theranostic devices in biomedical fields are also discussed.