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Back Cover: Enantiomeric separation and estimation of stiripentol by liquid chromatography mass spectrometer in human plasma
Author(s) -
Dubey Naveen Kr,
Jain Peeyush,
Haq KashifUl,
Fozdar B.I.
Publication year - 2020
Publication title -
separation science plus
Language(s) - English
Resource type - Journals
ISSN - 2573-1815
DOI - 10.1002/sscp.202070025
Subject(s) - chromatography , enantiomer , human plasma , chemistry , resolution (logic) , mass spectrometry , stereochemistry , computer science , artificial intelligence
DOI: 10.1002/sscp.202000034 The cover picture shows achiral Stiripentol that was to be extracted from the human plasma for a bioequivalence study for a test and a reference product of 500 mg dose. The enantiomers, R and S Stiripentol behave differently in the human body, hence it was necessary to first extract them from human plasma and then separate them using ultra‐fast liquid chromatography (UFLC) and chiral chromatography. High sensitivity for the method was achieved by using triple quad mass spectrometry in unit resolution mode. All these ideas put together resulted in a fantastic enantiomeric resolution with a complete base to base separation for Stiripentol with a resolution factor of more than 4.