Premium
Front Cover: Chromatographic separation of vildagliptin and L‐proline as in‐process impurity with the application of Youden's test and statistical analysis to test the robustness of the HPLC method
Author(s) -
Yehia Ali M.,
Elghobashy Mohamed Refaat,
Helmy Aya Hosam,
Youssef Nadia F.
Publication year - 2018
Publication title -
separation science plus
Language(s) - English
Resource type - Reports
ISSN - 2573-1815
DOI - 10.1002/sscp.201870022
Subject(s) - chromatography , vildagliptin , high performance liquid chromatography , chemistry , robustness (evolution) , impurity , front cover , materials science , cover (algebra) , engineering , organic chemistry , biochemistry , metformin , gene , endocrinology , medicine , mechanical engineering , diabetes mellitus
Sep Sci plus 2018, 1 , 395–403 DOI: 10.1002/sscp.201800005 The cover picture shows a new method for the separation of vildagliptin in presence of its starting material L‐proline as in process impurity by HPLC using cyano column with the application of Yoden's test to assess the robustness of the method. This method was successfully applied for the determination of vildagliptin in raw material and dosage form with good sensitivity and specificity.