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Front Cover: Nanoscopic Structural Fluctuations of Disassembling Microtubules Revealed by Label‐Free Super‐Resolution Microscopy (Small Methods 4/2021)
Author(s) -
Vala Milan,
Bujak Łukasz,
García Marín Antonio,
Holanová Kristýna,
Henrichs Verena,
Braun Marcus,
Lánský Zdeněk,
Piliarik Marek
Publication year - 2021
Publication title -
small methods
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 4.66
H-Index - 46
ISSN - 2366-9608
DOI - 10.1002/smtd.202170012
Subject(s) - microtubule , microscopy , nanoscopic scale , instability , depolymerization , biophysics , tubulin , materials science , optics , nanotechnology , physics , biology , microbiology and biotechnology , mechanics , polymer chemistry
In article number 2000985, Marek Piliarik and co‐workers develop a new light microscopy technique for label‐free detection and localization of conformation changes and subsequent depolymerization of tubulin segments from a tip of a disassembling microtubule. High‐speed imaging of the transient structural fluctuations suggests a stochastic mechanism of the microtubule dynamic instability.