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Landscape of Cell Communication in Human Dental Pulp
Author(s) -
Yin Wei,
Liu Gaoxia,
Li Jinhong,
Bian Zhuan
Publication year - 2021
Publication title -
small methods
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.66
H-Index - 46
ISSN - 2366-9608
DOI - 10.1002/smtd.202100747
Subject(s) - dental pulp stem cells , pulp (tooth) , microbiology and biotechnology , tlr2 , biology , cell , stem cell , tlr4 , dentistry , signal transduction , medicine , genetics
The cellular atlas of the stroma is not well understood. Here, the cell populations in human dental pulp through single‐cell RNA sequencing are profiled. Dental pulp stem cells, pulp cells, T cells, macrophages, endothelial cells, and glial cells are identified in human dental pulp. These cells support each other through sending growth signals. Based on the appearance of ligand–receptor pairs between two cell populations, pulp cells have the greatest communication with other cell types, while T cells have the least communication. In addition, T cells expressing TLR1 , TLR2 , and TLR4 , and endothelial cells expressing TLR4 , monitor bacterial invasion. These findings provide the census of normal dental pulp.