Premium
Emerging Biomaterials‐Based Strategies for Inhibiting Vasculature Function in Cancer Therapy
Author(s) -
Liu Minting,
Wu Caisheng,
Ke Lingjie,
Li Zhiguo,
Wu YunLong
Publication year - 2021
Publication title -
small methods
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.66
H-Index - 46
ISSN - 2366-9608
DOI - 10.1002/smtd.202100347
Subject(s) - nanomedicine , medicine , cancer , cancer research , vascular occlusion , cancer therapy , blood vessel , metastasis , biomedical engineering , nanotechnology , materials science , nanoparticle
Abstract The constant feeding of oxygen and nutrients through the blood vasculature has a vital role in maintaining tumor growth. Interestingly, recent endeavors have shown that nanotherapeutics with the strategy to block tumor blood vessels feeding nutrients and oxygen for starvation therapy can be helpful in cancer treatment. However, this field has not been detailed. Hence, this review will present an exhaustive summary of the existing biomaterial based strategies to disrupt tumor vascular function for effective cancer treatment, including hydrogel or nanogel‐mediated local arterial embolism, thrombosis activator loaded nano‐material‐mediated vascular occlusion and anti‐vascular drugs that block tumor vascular function, which may be beneficial to the design of anti‐cancer nanomedicine by targeting the tumor vascular system.