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Micro‐/Nano‐Structures on Biodegradable Magnesium@PLGA and Their Cytotoxicity, Photothermal, and Anti‐Tumor Effects
Author(s) -
Zhou Weixiao,
Zhang Yinling,
Meng Si,
Xing Chenyang,
Ma Mingze,
Liu Zhou,
Yang Chengbin,
Kong Tiantian
Publication year - 2021
Publication title -
small methods
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.66
H-Index - 46
ISSN - 2366-9608
DOI - 10.1002/smtd.202000920
Subject(s) - plga , photothermal therapy , in vivo , cytotoxicity , materials science , nanotechnology , magnesium , nanoparticle , in vitro , biomedical engineering , chemistry , biochemistry , medicine , microbiology and biotechnology , metallurgy , biology
The size and structural control of particulate carriers for imaging agents and therapeutics are constant themes in designing smart delivery systems. This is motivated by the causal relationship between geometric parameters and functionalities of delivery vehicles. Here, both in vitro and in vivo, the controlling factors for cytotoxicity, photothermal, and anti‐tumor effects of biodegradable magnesium@poly(lactic‐co‐glycolic acid (Mg@PLGA) particulate carriers with different sizes and shell thicknesses are investigated. Mg@PLGA microspheres fabricated by microfluidic emulsification are shown to have higher Mg encapsulation efficiency, 87%, than nanospheres by ultrasonic homogenization, 50%. The photothermal and anti‐tumor effects of Mg@PLGA spheres are found to be dictated by their Mg content, irrelevant to size and structural features, as demonstrated in both in vitro cell assays and in vivo mice models. These results also provide important implications for designing and fabricating stimuli‐responsive drug delivery vehicles.