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Proteomics and Precision Medicine
Author(s) -
Ding Chen,
Qin Zhaoyu,
Li Yan,
Shi Wenhao,
Li Lingling,
Zhan Dongdong,
Yang Wenjun
Publication year - 2019
Publication title -
small methods
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.66
H-Index - 46
ISSN - 2366-9608
DOI - 10.1002/smtd.201900075
Subject(s) - proteomics , proteome , precision medicine , computational biology , posttranslational modification , profiling (computer programming) , data science , computer science , bioinformatics , medicine , biology , pathology , biochemistry , gene , enzyme , operating system
During the last decade, great progress has been made in mass spectrometry rendering the identification of 6000 proteins in an hour and up to 10 000 proteins in half a day. The proteome has been widely applied in a variety of studies in the life sciences, for dissecting protein profiling, protein–protein interactions, post‐translational‐modification, etc. Since the improvement of the proteome screening efficiency and the decreasing of the cost in sample measurement, the growing requirement of deep application of proteomics has been raised recently in clinical research, foretelling an era in which proteomics will enable personally tailored therapies for patients. This review describes the cutting‐edge progression of next‐generation proteomics and highlights its potential in precision medicine in the future.