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Nanotoxicity: A Proteoliposome Method for Assessing Nanotoxicity on Synaptic Fusion and Membrane Integrity (Small Methods 11/2017)
Author(s) -
Crowe Michael,
Lai Ying,
Wang Yongyao,
Lu Jiuwei,
Zhao Minglei,
Tian Zhiqi,
Long Jiangang,
Zhang Peng,
Diao Jiajie
Publication year - 2017
Publication title -
small methods
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.66
H-Index - 46
ISSN - 2366-9608
DOI - 10.1002/smtd.201770111
Subject(s) - nanotoxicology , exocytosis , membrane , lipid bilayer fusion , nanotechnology , nanomaterials , leakage (economics) , materials science , chemistry , biophysics , nanoparticle , biology , biochemistry , economics , macroeconomics
An in vitro vesicle system that mimics neuronal exocytosis is employed for nanotoxicity testing by Jiajie Diao and co‐workers in article number 1700207 . The experimental scheme consists of leakage and content‐mixing experiments to test the effects of nanomaterials on membrane integrity and synaptic fusion, respectively. The results demonstrate the potential of this system as a novel in vitro platform for assessing the biocompatibility of nanomaterials, drug molecules, and other substances. These leakage and content‐mixing experiments may offer a faster and easier approach for measuring nanotoxicity.