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Supramolecular Vesicles for Stimulus‐Responsive Drug Delivery
Author(s) -
Xing Pengyao,
Zhao Yanli
Publication year - 2018
Publication title -
small methods
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.66
H-Index - 46
ISSN - 2366-9608
DOI - 10.1002/smtd.201700364
Subject(s) - nanocarriers , supramolecular chemistry , nanotechnology , drug delivery , biocompatibility , vesicle , controlled release , cancer therapy , materials science , chemistry , medicine , cancer , biochemistry , membrane , crystal structure , metallurgy , crystallography
Developing smart controlled‐release systems for cancer therapy is highly desired in biomedicine. In order to improve therapeutic efficacy and lower undesired side effects, the construction of stimulus‐responsive nanocarriers is a favorable solution. Emerging supramolecular self‐assemblies possessing intrinsic dynamic and adaptive features present promising capabilities for the fabrication of stimulus‐responsive drug‐release systems. Dynamic supramolecular vesicles have attracted considerable attention as therapeutic carriers ascribed to their advantages of high‐cargo‐loading capacity/feasibility, excellent biocompatibility, and facile functionalization. Here, a summary and discussion of recent significant development of vesicles constructed by supramolecular self‐assembly for stimulus‐responsive drug delivery and therapeutics is given. Through presenting some representative studies, strategies regarding the design, synthesis, characterization, and biomedical applications of supramolecular vesicle carriers are highlighted according to various stimulus triggers. The aim is to provide a quick research update in this rapidly developing field.