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3D‐Printed Biomaterials for Guided Tissue Regeneration
Author(s) -
Zhang Ben,
Song Jie
Publication year - 2018
Publication title -
small methods
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.66
H-Index - 46
ISSN - 2366-9608
DOI - 10.1002/smtd.201700306
Subject(s) - 3d printing , scaffold , regeneration (biology) , tissue engineering , regenerative medicine , materials science , nanotechnology , 3d printed , fabrication , biomedical engineering , computer science , engineering , chemistry , cell , composite material , medicine , biochemistry , microbiology and biotechnology , biology , alternative medicine , pathology
Abstract Fabrication of 3D scaffolds with interconnected macro‐/microporosity, compositional gradient, biological cues, and precise geometric configurations matching with that of a tissue defect, along with the choice of appropriate biomaterials, is central to the success of scaffold‐guided tissue‐regeneration strategies. Customized high‐speed 3D‐printing technology enables efficient fabrication of 3D scaffolds for regenerative‐medicine applications. In addition to recent technological advances in 3D‐printing methods and instrumentation, progress has been made in the expansion of printable biomaterials and cell‐laden bioinks. Here, a brief overview of the 3D‐printing techniques most commonly used for biomedical applications is given, followed by a discussion of common bioceramics, natural biopolymers, and synthetic degradable thermoplastic polymers, as well as their cell/biofactor‐laden composites used for 3D printing. Advantages and limitations of these printing techniques and bioinks for various tissue repair/regeneration applications are highlighted.