Open AccessSpatially Guided Construction of Multilayered Epidermal Models Recapturing Structural Hierarchy and Cell–Cell Junctions
Author(s) -
Zhai Haiwei,
Jin Xiaowei,
Minnick Grayson,
Rosenbohm Jordan,
Hafiz Mohammed Abdul Haleem,
Yang Ruiguo,
Meng Fanben
Publication year - 2022
Publication title -
small science
Language(s) - English
Resource type - Journals
ISSN - 2688-4046
DOI - 10.1002/smsc.202270022
Subject(s) - epidermis (zoology) , hierarchy , 3d bioprinting , cell , wound healing , tissue engineering , microbiology and biotechnology , computer science , chemistry , medicine , biology , biomedical engineering , anatomy , immunology , biochemistry , economics , market economy
Tissue Engineering In article number 2200051 , Ruiguo Yang, Fanben Meng, and co‐workers develop a wound‐healing‐inspired strategy for the construction of stratified skin models, by combining 3D bioprinting and guided cell self organization. The biofabricated tissue architecture that recapitulates the fine structural hierarchy of the epidermis will establish an in vitro platform to study progression of skin diseases, such as the fatal pemphigus vulgaris.