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Novel Core–Shell Polyamine Phosphate Nanoparticles Self‐Assembled from PEGylated Poly(allylamine hydrochloride) with Low Toxicity and Increased In Vivo Circulation Time (Small 35/2021)
Author(s) -
Andreozzi Patrizia,
Simó Cristina,
Moretti Paolo,
Porcel Joaquin Martinez,
Lüdtke Tanja Ursula,
Ramirez Maria de los Angeles,
Tamberi Lorenza,
Marradi Marco,
Amenitsch Heinz,
Llop Jordi,
Ortore Maria Grazia,
Moya Sergio Enrique
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202170182
Subject(s) - polyamine , peg ratio , polyethylene glycol , allylamine , in vivo , nanoparticle , chemistry , biophysics , materials science , biochemistry , nanotechnology , organic chemistry , polyelectrolyte , polymer , biology , microbiology and biotechnology , finance , economics
Polyamine Phosphate Nanoparticles In article number 2102211, Sergio Enrique Moya and co‐workers present supramolecular polyamine phosphate nanoparticles (PANs) assembled from polyamines modified with polyethylene glycol (PEG) that vary size and charge depending on the number of PEG molecules per polyamine. PEGylated PANs with 10 PEG chains per polyamine display a core shell structure and show a longer circulation in vivo and reduced toxicological endpoints in vitro through the screening of positive charges by the PEG shell.