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Continuous Monitoring Reveals Protective Effects of N ‐Acetylcysteine Amide on an Isogenic Microphysiological Model of the Neurovascular Unit (Small 32/2021)
Author(s) -
Matthiesen Isabelle,
Voulgaris Dimitrios,
Nikolakopoulou Polyxeni,
Winkler Thomas E.,
Herland Anna
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202170167
Subject(s) - oxidative stress , neurovascular bundle , blood–brain barrier , acetylcysteine , nanotechnology , antioxidant , multicellular organism , biophysics , chemistry , neuroscience , materials science , biology , biochemistry , anatomy , central nervous system , cell
Microphysiological Systems In article number 2101785, Thomas E. Winkler, Anna Herland, and co‐authors describe a microphysiological blood‐brain barrier model that captures the multicellular interactions of iPS‐derived cells. The integrated electrical sensors, facilitated by PDMS‐free fabrication, allow for real‐time monitoring of how the barrier responds to oxidative stress and antioxidant prophylaxis.