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Microfluidics: Stochastic and Age‐Dependent Proteostasis Decline Underlies Heterogeneity in Heat‐Shock Response Dynamics (Small 30/2021)
Author(s) -
VerttiQuintero Nadia,
Berger Simon,
Casadevall i Solvas Xavier,
Statzer Cyril,
Annis Jillian,
Ruppen Peter,
Stavrakis Stavros,
Ewald Collin Y.,
Gunawan Rudiyanto,
deMello Andrew J.
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202170157
Subject(s) - proteostasis , shock (circulatory) , microfluidics , biology , heat shock protein , heat shock , dynamics (music) , hsf1 , throughput , sorting , microbiology and biotechnology , nanotechnology , computer science , genetics , materials science , physics , medicine , gene , hsp70 , telecommunications , wireless , programming language , acoustics
In article number 2102145, Collin Y. Ewald, Rudiyanto Gunawan, and co‐workers highlight a microfluidic device used for sorting adult C. elegans populations—in a high‐throughput manner—based on individual GFP expression. The heterogeneous dynamic heat‐shock response, its relation to proteostasis, and how it can predict lifespan are thoroughly studied. Image credit: Mrs. Yujia Ma.