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Chemoimmunotherapy: Coordination and Redox Dual‐Responsive Mesoporous Organosilica Nanoparticles Amplify Immunogenic Cell Death for Cancer Chemoimmunotherapy (Small 26/2021)
Author(s) -
Zhang Fan,
Chen Fangman,
Yang Chao,
Wang Lei,
Hu Hanze,
Li Xuezhao,
Zheng Xiao,
Wang Zheng,
Chang Zhimin,
Li Tianyu,
Li Li,
Ge Mingfeng,
Du Jinzhi,
Sun Wen,
Dong Wenfei,
Shao Dan
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202170130
Subject(s) - chemoimmunotherapy , immunogenic cell death , diselenide , cancer research , materials science , nanoparticle , cancer cell , chemistry , medicine , cancer , nanotechnology , immunotherapy , selenium , metallurgy
In article number 2100006, Wen Sun, Wen‐fei Dong, Dan Shao, and co‐workers fabricate diselenide‐bridged mesoporous organosilica nanoparticles for coordination and redox dual‐responsive delivery of chemotherapeutic ruthenium compound KP1339. Such immunogenic cell death nano‐amplifier performed robust suppression on primary and distant tumor growth, as well as pulmonary metastasis of breast cancer with low systematic toxicity when combined with anti‐PD‐L1.