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Diagnosis of Autoimmune Diseases: Nanocage‐Based Capture‐Detection System for the Clinical Diagnosis of Autoimmune Disease (Small 25/2021)
Author(s) -
Zhang Yanan,
Li Yingni,
Zhang Jianlin,
Chen Xuehui,
Zhang Ruofei,
Sun Guoming,
Jiang Bing,
Fan Kelong,
Li Zhanguo,
Yan Xiyun
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202170126
Subject(s) - nanocages , autoimmune disease , antibody , immunology , antigen , disease , medicine , biology , pathology , biochemistry , catalysis
In article number 2101655, Kelong Fan, Zhanguo Li, Xiyun Yan, and co‐workers develop a highly sensitive platform for diagnosis of autoimmune disease. The antigen and anti‐Fc peptides are displayed on the surface of ferritin to construct nanocage‐based capture‐detection system. Multimeric display significantly enhances their binding ability to corresponding antibodies, thus improving the detection sensitivity 100–1000‐folds higher than that of conventional ELISA methods.