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Gene Silencing: Therapeutic Gene Silencing Using Targeted Lipid Nanoparticles in Metastatic Ovarian Cancer (Small 19/2021)
Author(s) -
Singh Manu Smriti,
Ramishetti Srinivas,
LandesmanMilo Dalit,
Goldsmith Meir,
Chatterjee Sushmita,
Palakuri Ramesh,
Peer Dan
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202170086
Subject(s) - gene silencing , ovarian cancer , cancer research , rna interference , cancer , small interfering rna , gene , biology , medicine , rna , genetics
Lipid nanoparticles encapsulating two different small interfering ribonucleic acids are developed that block essential pathways for cancer cell survival. Targeting of metastasized ovarian cancer cells is further enhanced by coating nanoparticles with hyaluronan. Robust gene silencing in key tissues involved in ovarian cancer pathophysiology in an advanced ovarian cancer mouse model and improved median and overall survival are demonstrated by Dan Peer and co‐workers in article number 2100287.