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Drug Screening Tools: A Spheroid‐Forming Hybrid Gold Nanostructure Platform That Electrochemically Detects Anticancer Effects of Curcumin in a Multicellular Brain Cancer Model (Small 15/2021)
Author(s) -
Suhito Intan Rosalina,
Angeline Novi,
Lee KwangHo,
Kim Huijung,
Park Chun Gwon,
Luo Zhengtang,
Kim TaeHyung
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202170066
Subject(s) - spheroid , curcumin , multicellular organism , nanotechnology , nanostructure , drug , anticancer drug , materials science , cancer , in vitro , cancer research , chemistry , biology , pharmacology , medicine , cell , biochemistry
In article number 2002436, Tae‐Hyung Kim and co‐workers demonstrate a novel multifunctional hybrid platform that enables spontaneous cancer spheroids formation on the surface and real‐time non‐destructive electrochemical monitoring of spheroid viability simultaneously. The platform allows for mimicking the complex three‐dimensional cellular networks and multicellular characteristics of real solid tumors in vitro, which will be highly useful for high‐throughput anticancer drug screening.