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Liver‐on‐a‐Chip: Bioengineered Multicellular Liver Microtissues for Modeling Advanced Hepatic Fibrosis Driven Through Non‐Alcoholic Fatty Liver Disease (Small 14/2021)
Author(s) -
Cho HyunJong,
Kim HanJun,
Lee KangJu,
Lasli Soufian,
Ung Aly,
Hoffman Tyler,
Nasiri Rohollah,
Bandaru Praveen,
Ahadian Samad,
Dokmeci Mehmet R.,
Lee Junmin,
Khademhosseini Ali
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202170061
Subject(s) - hepatic stellate cell , fatty liver , multicellular organism , alcoholic liver disease , pathogenesis , liver fibrosis , fibrosis , pathology , hepatic fibrosis , medicine , cancer research , disease , cell , chemistry , cirrhosis , biochemistry
In article number 2007425, Junmin Lee, Ali Khademhosseini, and co‐workers present a breakthrough for modeling of non‐alcoholic fatty liver disease (NAFLD) based on bioengineered multicellular liver microtissues and a liver‐on‐a‐chip system. The microtissues consisting of four major liver cell types (primary human hepatocytes, stellate cells, Kupffer cells, and endothelial cells) recapitulate the pathogenesis of hepatic fibrosis driven by NAFLD.