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Iodine Immobilized Metal–Organic Framework for NIR‐Triggered Antibacterial Therapy on Orthopedic Implants
Author(s) -
Teng Wangsiyuan,
Zhang Zengjie,
Wang Yikai,
Ye Yuxiao,
Yinwang Eloy,
Liu An,
Zhou Xingzhi,
Xu Jianxiang,
Zhou Chengwei,
Sun Hangxiang,
Wang Fangqian,
Zhang Lingling,
Cheng Chongguang,
Lin Peng,
Wu Yan,
Gou Zhongru,
Yu Xiaohua,
Ye Zhaoming
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202102315
Subject(s) - iodine , materials science , chemistry , antibacterial activity , zeolitic imidazolate framework , nanotechnology , nuclear chemistry , biomedical engineering , metal organic framework , organic chemistry , bacteria , medicine , genetics , biology , adsorption
Iodine has been known as an effective disinfectant with broad‐spectrum antimicrobial potency yet without drug resistance risk when used in clinic. However, the exploration of iodine for antibacterial therapy in orthopedics remains sparse due to its volatile nature and poor solubility. Herein, leveraging the superior absorption capability of metal–organic frameworks (MOFs) and their inherent photocatalytic properties, iodine‐loaded MOF surface is presented to realize responsive iodine release along with intracellular reactive oxygen species(ROS) oxidation under near‐infrared (NIR) exposure to achieve synergistic antibacterial effect. Iodine is successfully loaded using vapor deposition process onto zeolitic imidazolate framework‐8(ZIF‐8), which is immobilized onto micro arc oxidized titanium via a hydrothermal approach. The combination of NIR‐triggered iodine release and ZIF‐8 mediated ROS oxidative stress substantially augments the antibacterial efficacy of this approach both in vitro and in vivo. Furthermore, this composite coating also supported osteogenic differentiation of bone marrow stromal cells, as well as improved osseointegration of coated implants using an intramedullary rat model, suggesting improvement of antibacterial efficacy does not impair osteogenic potential of the implants. Altogether, immobilization of iodine via MOF on orthopedic implants with synergistic antibacterial effect can be a promising strategy to combat bacterial infections.