Premium
Defect‐Engineered Nanozyme‐Linked Receptors
Author(s) -
Wu Yu,
Wen Jing,
Xu Weiqing,
Huang Jiajia,
Jiao Lei,
Tang Yinjun,
Chen Yifeng,
Yan Hongye,
Cao Shiyu,
Zheng Lirong,
Gu Wenling,
Hu Liuyong,
Zhang Lizhi,
Zhu Chengzhou
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202101907
Subject(s) - receptor , nanotechnology , transduction (biophysics) , signal transduction , chemistry , materials science , biochemistry
Though nanozymes are successfully applied in various areas, the increasing demands facilitate the exploitation of nanozymes possessing higher activity and more functions. Natural enzyme‐linked receptors (ELRs) are critical components for signal transductions in vivo by expressing activity variations after binding with ligands. Inspired by this, the defect‐engineered carbon nitrides (DCN) are reported to serve as nanozyme‐linked receptors (NLRs). For one thing, cyano defects increase the enzyme‐like activity by a factor of 109.5. For another, DCN‐based NLRs are constructed by employing cyano groups as receptors, and variable outputs are ensued upon the addition of ion ligands. Significantly, both the cascade effect and electronic effect are demonstrated to contribute to this phenomenon. Finally, NLRs are used for pattern recognition of metal ions, indicating the signal transduction ability of NLRs as well. This work not only provides great promise of defect engineering in nanozymes, but also contributes to the design of artificial ELRs.