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Red Phosphorus Decorated TiO 2 Nanorod Mediated Photodynamic and Photothermal Therapy for Renal Cell Carcinoma
Author(s) -
Yang Chengyu,
Zhu Yukun,
Li Daohao,
Liu Yiming,
Guan Chen,
Man Xiaofei,
Zhang Shuchao,
Zhang Lixue,
Yang Dongjiang,
Xu Yan
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202101837
Subject(s) - photodynamic therapy , photothermal therapy , propidium iodide , clear cell renal cell carcinoma , in vivo , nanorod , cancer research , materials science , photosensitizer , reactive oxygen species , apoptosis , programmed cell death , chemistry , medicine , nanotechnology , renal cell carcinoma , pathology , biology , photochemistry , biochemistry , microbiology and biotechnology , organic chemistry
Clear cell renal cell carcinoma (ccRCC) is a serious and tenacious disease. Photodynamic therapy (PDT) and photothermal therapy (PTT) are effective means of cancer treatment. However, PDT combined with PTT has been rarely reported in ccRCC treatment. In the present study, by developing the core–shell structured TiO 2 @red phosphorus nanorods (TiO 2 @RP NRs) as a photosensitizer, the feasibility and effectiveness of synchronous PDT and PTT treatments for ccRCC are demonstrated. The core–shell structured TiO 2 @RP NRs are synthesized to drive the PDT and PTT for ccRCC, in which the RP shell is the sensitizer even in the near‐infrared (NIR) region. The optimized TiO 2 @RP NRs can respond to NIR and produce local heat under irradiation. The NRs are estimated in ccRCC treatments via cell counting kit‐8 assay, propidium iodide staining, qRT‐PCR, and reactive oxygen species (ROS) probes in vitro, while terminal deoxynucleotidyl transferase dUTP nick‐end labeling is conducted in vivo. After NIR irradiation, TiO 2 @RP NRs can efficiently kill ccRCC cells by producing local heat and ROS and cause low injury to normal kidney cells. Furthermore, treatment with TiO 2 @RP NRs and NIR can kill significant numbers of deep‐tissue ccRCC cells in vivo. This work highlights a promising photo‐driven therapy for kidney cancer.