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Spatial Heterodyne Offset Raman Spectroscopy Enabling Rapid, High Sensitivity Characterization of Materials’ Interfaces
Author(s) -
Cui Han,
Glidle Andrew,
Cooper Jonathan M.
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202101114
Subject(s) - raman spectroscopy , optics , heterodyne (poetry) , materials science , offset (computer science) , coherent anti stokes raman spectroscopy , raman scattering , spectrometer , frequency domain , fourier transform spectroscopy , spectroscopy , physics , computer science , fourier transform infrared spectroscopy , acoustics , quantum mechanics , computer vision , programming language
Spatially offset Raman spectroscopy is integrated with a fiber‐coupled spatial heterodyne spectrometer to collect Raman spectra from deep within opaque or scattering materials. The method, named spatial heterodyne offset Raman spectroscopy generates a wavenumber‐dependent spatial phase shift of the optical signal as a “spectral” image on a charge‐coupled device detector. The image can be readily processed from the spatial domain using a single, simple, and “on‐the‐fly” Fourier transform to generate Raman spectra, in the frequency domain. By collecting all of the spatially offset Raman scattered photons that pass through the microscope's collection objective lens, the methodology gives an improvement in the Raman sensitivity by an order of magnitude. The instrumentation is both mechanically robust and “movement‐free,” which when coupled with the associated advantages of highly efficient signal collection and ease of data processing, enables rapid interfacial analysis of complex constructs based on established biomaterials models.