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NIR‐II Responsive Hollow Magnetite Nanoclusters for Targeted Magnetic Resonance Imaging‐Guided Photothermal/Chemo‐Therapy and Chemodynamic Therapy
Author(s) -
Wang Xingyu,
Li Changwei,
Qian Junchao,
Lv Xiaotong,
Li Hong,
Zou Jinglu,
Zhang Jiahui,
Meng Xiangfu,
Liu Hongji,
Qian Yong,
Lin Wenchu,
Wang Hui
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202100794
Subject(s) - photothermal therapy , nanoclusters , magnetic resonance imaging , materials science , hydrogen peroxide , photodynamic therapy , magnetite , nanotechnology , nanocages , nuclear magnetic resonance , chemistry , medicine , catalysis , organic chemistry , metallurgy , radiology , physics
Abstract Phototherapy in the second near‐IR (1000–1700 nm, NIR‐II) window has achieved much progress because of its high efficiency and relatively minor side effects. In this paper, a new NIR‐II responsive hollow magnetite nanocluster (HMNC) for targeted and imaging‐guided cancer therapy is reported. The HMNC not only provides a hollow cavity for drug loading but also serves as a contrast agent for tumor‐targeted magnetic resonance imaging. The acid‐induced dissolution of the HMNCs can trigger a pH‐responsive drug release for chemotherapy and catalyze the hydroxyl radical (·OH) formation from the decomposition of hydrogen peroxide for chemodynamic therapy. Moreover, the HMNCs can adsorb and convert NIR‐II light into local heat (photothermal conversion efficacy: 36.3%), which can accelerate drug release and enhance the synergistic effect of chemo‐photothermal therapy. The HMNCs show great potential as a versatile nanoplatform for targeted imaging‐guided trimodal cancer therapy.