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Tumor‐Specific Multipath Nucleic Acid Damages Strategy by Symbiosed Nanozyme@Enzyme with Synergistic Self‐Cyclic Catalysis
Author(s) -
Zhao Yan,
Kong Weiheng,
Wang Peng,
Song Guosheng,
Song ZhiLing,
Yang Yue,
Wang Youjuan,
Yin Baoli,
Rong Pengfei,
Huan Shuangyan,
Zhang XiaoBing
Publication year - 2021
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.202100766
Subject(s) - nucleic acid , nucleic acid metabolism , chemistry , catalysis , biochemistry , enzyme , redox , glutathione , catalytic efficiency , microbiology and biotechnology , biophysics , biology , rna , gene , organic chemistry
The high proliferation efficiency, redox imbalance, and elevated nucleic acid repair capabilities of tumor cells severely restrict the theranostic efficacy. Selectively interference chaotic tumors with devastating nucleic acid damages (NUDs) properties are expected to overcome theranostic barriers. Here, an exquisite catalytic‐based strategy with comprehensive NUDs mechanisms is demonstrated. In this regard, enzyme (glucose oxidase, GOD) symbioses nanozyme Cu 3+ x (PO 4 ) 2 through biomineralization (abbreviated as Cu@GOD), GOD can disorder the metabolism by consuming glucose, thereby inhibiting the nutrition supply for nucleic acid repair. GOD‐catalyzed H 2 O 2 guarantees the self‐cyclic glutathione depletion and reactive oxygen species generation caused by Cu 3+ x (PO 4 ) 2 , resulted the reduced antioxidation defense and enhanced oxidation assault, ensures an indiscriminate NUDs ability. Moreover, the high photothermal effect of Cu 3+ x (PO 4 ) 2 induces effective tumor inhibition. Consequently, this substantial multipath NUDs strategy, with potentials of suppressing the cytoprotective mechanisms, amplifying the cellular oxidative stress, and disrupting the redox balance to ensure substantial irreversible NUDs, completely breaks the obstacle of chaotic tumors, providing new conceptual thinking for tumor proliferation inhibition.